News Stories
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IBBR Study Reveals How T Cells Recognize a Common Cancer Mutation
Our body’s immune system must be able to differentiate infected and diseased cells from healthy cells. T cells play an important role in this process. Using T cell receptors (TCRs) on their surfaces, they travel around the body searching for antigens that match their TCRs and then trigger an immune...
Register TODAY for the 5th Annual Early Career Symposium at IBBR
The Institute for Bioscience and Biotechnology Research (IBBR) invites you to participate in the Fifth Annual Early Career Symposium at IBBR on September 16, 2026 from 8:30am-5:00pm at our facility in Rockville, Maryland. This year's symposium builds on the success of our past symposiums which were attended by 150 participants...
IBBR Ph.D. Student Earns Prestigious 2026 Summer Research Fellowship
IBBR proudly congratulates doctoral student Holly Hemesath on receiving the Graduate Student Summer Research Fellowship for 2026, a competitive award that supports Ph.D. students at critical stages of their training. Holly is a member of Dr. Yanxin Liu’s group at the Institute for Bioscience & Biotechnology Research (IBBR) and in...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Connecting
IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Upcoming Events
Seminar: Asher Williams, Columbia University
Seminar: Sarah Keane, University of Michigan
Recent Publications
Structural basis for oligoclonal T cell recognition of a shared NRAS cancer neoantigen.
T cell receptors (TCRs) specific for cancer neoantigens are important for anti-tumor immunity and immunotherapy. To understand the structural basis for T cell recognition of cancer neoantigens, we...
Operationalizing digital twins in biomanufacturing through interoperable process analytical technology.
The integration of Process Analytical Technologies (PAT) within digital twin architecture represents an important advancement in biopharmaceutical manufacturing. While existing literature has...
Molecular Interpretation of Temperature-Induced DNA Melting Monitored through Base Dipole Moment Changes as a Surrogate of the Hypochromic Shift.
DNA stability measurements have long been monitored by the hypochromic shift; the increase in UV absorption upon going from native to non-native states is attributed to changes in base transition...
Metabolite Fraction Libraries for Quantitative NMR Metabolomics.
Nuclear magnetic resonance (NMR) has unique strengths in metabolomics studies, particularly in quantifying mixtures and elucidating the structures of unknown molecules. One-dimensional (1D) proton...
Glycoengineered Recombinant Alpha1-Antitrypsin Results in Comparable In Vitro and In Vivo Activities to Human Plasma-Derived Protein.
Alpha-1-antitrypsin (A1AT) is a multifunctional, clinically important, high-value therapeutic glycoprotein that can be used for the treatment of many diseases, such as A1AT deficiency, diabetes,...